Friday, December 16, 2005

This year in Medicine

Alzheimer's disease - A research from University of South Carolina found that inflammation caused by lost or loose tooth, and the resulting infection can quadruple the risk of developing Alzheimer's.

Aspirin - It has been proved that low doses of Aspirin taken daily can reduce the risk of a first heart attack by an average of 30% in men but a recent publication based on a 10 year long study on Women's health found no difference between the results in women for those who were on placebo and those on Aspirin. The only age group that proved positive to the previous study was the age group greater than 65 years. This probably is related to the estrogen level which decreases after menopause. Estrogen is protective for the heart. Nevertheless low-dose aspirin did reduce the risk of stroke in women of all ages.

Asthma - New York University found two more risk factors for Asthma - Flour and Laughter

Autism - Autism has been said to be related to vaccination in previous studies but a recent study by the Mayo Clinic challenges this opinion. They found that the apparent increase in Autism can be traced to improved awareness of the disease and the changes in the way the condition is diagnosed but not necessarily to immunizations

Avian Flu - The possiblity of a flu pandemic has kept health officials all over the world busy. The dreaded H5N1 strain of the virus has affected 132 people and half of them have already died. The only reason more humans haven't died is that the particular flu virus has difficulty transmitting from one person to another. Although a single mutation can change the whole scenario.

BiDiL - BiDil is a prescription medicine for the treatment of heart failure in self-identified African American patients who are already being treated with standard therapy. It was recently approved by the U.S. Food and Drug Administration (FDA). BiDil combines two ingredients (isosorbide dinitrate and hydralazine hydrochloride) that cause arteries and veins to dilate, or expand. BiDil is indicated for the treatment of heart failure in addition to standard therapy in self-identified black patients to:
- Improve survival
- Prolong time to first hospitalization for heart failure
- Improve patient-reported functional status

Cancers
Breast Cancer - Herceptin, a powerful drug for treating advanced cases of HER2- positive breast cancers , has been found to reduce recurrence of early stage of HER2 cancers by 46%.
Colon Cancer - Two studies -
(1) One study reported that patients taking 1,200 mg of the mineral daily for four years had 36% fewer colon polyps, even five years after the trial ended, than those who didn't take calcium.
(2) In a separate study, women taking more than 800 mg of Calcium every day reduced the risk of colorectal cancer by 46%.
Prostate Cancer - The prostate uses Vitamin D - that the body makes in response to sunlight - to grow normally and crowd out cancer cells in the organ. The study found that men with high exposure to sun had half the risk to prostate cancer than men who spent most of their days indoors.

Cloning - World's first genetically cloned puppy, Snuppy, created from a single cell from the ear of an Afghan hound by Woo Suk Hwang and team at the Seoul University.

Diabetes - According to a 12 year study of milk drinking men, switching to low- or non-fat dairy products reduces the risk of diabetes. Another risk factor according to another study is exceeding the BMI of 30, which actually doubles the risk.

- Newly developed insulin delivery modes - Nasal sprays and Inhalers
- Other products - Blood sugar monitors with less painful laser lancets

Down Syndrome - A new screening test which factors in the mother's age, a fetal ultrasound measurement and related hormones can be conducted in the 11th week of pregnancy and has shown to have 87% accuracy. An integrated test that combines result from first- and second trimester screens in 96% accurate.

Episiotomy - A compilation of 55 years of research showed that women who have episiotomies are at a greater risk of insjury, take longer time to heal and don't have a better sex life.

Fish Oil ( Omega - 3s) - Oil from Salmon, Sardines and Mackerel has been known to be protective for heart but a recent study showed that if taken in excess, they increased heart- rhythm abnormalities , especially in patients with implantable defibrillators.

Heart - A study in Johns Hopkins has managed to find the pathophysiology of Stress Cardiomyopathy ( also known as " Broken Heart Syndrome " - often mistaken for a classic heart attack). The syndrome is caused by a surge of adrenaline and other stress hormones that temporarily stuns the heart muscle. There is no permanent damage to the heart and patients usually show a dramatic recovery in a few days.

Marijuana - One controlled study showed that a canabis extract " Sativex " not only alleviated the pain of Rheumatoid arthritis but actually suppressed the disease.
An earlier study showed that synthetic cannabinoids, the chemicals in marijuana, can reduce the inflammation in the brain and may protect it from the cognitive decline associated with alzheimer's disease.

Malaria - The three dose regimen of Vaccine RTS,S ( developed by Glaxo Smith Kline ) decreased the number of clinical cases in age group 1-4 by 36% and the number of severe cases fell by 50%.

Polio - 2005 was supposed to be the year of world-wide eradication of Polio but 1,499 cases were reported. Health officials world wide are optimistic about eliminating the paralytic scourge by 2006.

Friday, December 09, 2005

Paroxetine and birth defects

FDA: Paxil Linked to Birth Defects

ROCKVILLE, Md., Dec. 8-The FDA warned doctors today that preliminary results implicate the antidepressant Paxil (paroxetine) with an increased risk of birth defects. The FDA informed doctors that results of new studies suggest that Paxil use during the first trimester increases the risk of congenital heart defects in the developing fetus. The FDA advised physicians to discuss the potential risk of birth defects with women taking Paxil who plan to become pregnant or who are in the first trimester of pregnancy. Doctors should consider discontinuing Paxil in these patients and switching to another antidepressant if indicated. In some patients, the benefits of continuing Paxil may be greater than the potential risk to the fetus, the FDA said. In general, however, the FDA advised that the drug should not be taken during pregnancy. But women who are taking Paxil should consult their physicians before stopping the drug.

The FDA action was prompted by results of two studies that showed that women who took Paxil during the first three months of pregnancy were about one and a half to two times as likely to have a baby with a heart defect as women who received other antidepressants or women in the general population. The most common defects were atrial and ventricular septal defects that ranged in severity from minor, self-resolving defects to serious defects that required surgical repair. The FDA said that in one of the studies, the risk of heart defects in babies whose mothers had taken Paxil early in pregnancy was about 2%, compared with a 1% expected risk in the general population.

In the other study, the risk of heart defects in babies whose mothers had taken Paxil in the first three months of pregnancy was 1.5% compared to 1% risk for women taking other antidepressants. The FDA said it asked Paxil's manufacturer, GlaxoSmithKline, to change the drug's label to upgrade the pregnancy warning from a category C to a category D, a higher level warning. The company changed the label two months ago to add data from one of the studies. The latest label change reflects data from both studies, the FDA said.

Med News 12/09/05

Sunflower Seeds, Pistachios Among Top Nuts For Lowering Cholesterol
A Jekyll-and-Hyde Enzyme's Role (Cdk5) In Alzheimer's
Acne, Milk And The Iodine Link
TLR4 Gene Found To Protect Against Tumor Development And Chronic Lung Inflammation
Researchers Discover A Protein Responsible For Shaping The Nervous System
Low-dose Chemotherapy Plus Antiangiogenesis Drug Has Activity In Advanced Breast Cancer

Wednesday, December 07, 2005

Cardiovascular Pharmacology

http://lysine.pharm.utah.edu/netpharm/netpharm_00/notes/introcv.htm#Intro
http://lysine.pharm.utah.edu/netpharm/netpharm_00/notes.html

New drug for heart failure

UAB Dec. 5
Clinical trials (REVIVE II - Randomized Multicenter Evaluation of I.V. Levosimedan Efficiency) show that patients receiving Levosimendan in addition to standard treatment had a greater likelihood of clinical improvement anda lower risk of clinical deterioration than those who only received standard therapy.

Levosimendan is a calcium sensitiser that can be administered intravenously (IV) to patients with acute decompensated congestive heart failure (CHF). At therapeutic dosages levosimendan enhances myocardial contractility without increasing oxygen requirements, and causes coronary and systemic vasodilation.

In clinical trials levosimendan has been shown to reduce the risk of worsening CHF or death compared with dobutamine and placebo in patients with decompensated CHF. The drug is well tolerated, does not appear to be proarrhythmic, has minimal potential for interactions with other drugs, and does not reduce short-or long-term (30-day) survival.

Thus, unlike some other agents administered to improve contractility in decompensated heart failure, IV levosimendan appears to offer therapeutic benefits without risk of arrhythmogenesis and/or uncertain impacts on survival.

Sunday, December 04, 2005

Med News 12/04/2005

West Nile Virus Screening approved
Health Coverage of Young Widens With States' Aid
Atomoxetine HCI - New drug for ADHD
Only 8% of Eligible Seniors Approved for Medicare Drug Program

Rafi - The Virtuoso

I am a huge fan of Rafi ... my collection of Rafi songs ranges from his first song with K.L. Saigal to his last song "Tu kahin aas paas hai dost " from "Aas Paas". But there are a couple of songs that he sang for Dev Anand that have a class of their own. Here's one that I love the most - can't explain why.

Koi sone ka dilwala - Maya ( *ing Dev Anand)



and this one was his last recorded song as mentioned above...



... I wish there was more to it ...

Saturday, December 03, 2005

Today's Med News

New site for checking drug interactions http://www.drugdigest.org/DD/Interaction/ChooseDrugs/1,4109,,00.html
http://www.rxlist.com/interact.htm
http://www.drugs.com/drug_interactions.html
First Face transplant successful
http://www.iht.com/articles/2005/12/02/news/face.php
Bird Flu detected in Ukraine
http://www.japantoday.com/e/?content=news&cat=8&id=357340

Aha!

Atlast... I got myself something of my own on the internet.

I am so happy today... I got the complete John Denver and Johnny Cash Collection today. Yeah!

I have two tests next week and I don't want to study ...someone please kick me in my ass! Maybe that will straighten me up .

Kaiser Daily Global Health Policy Report